Detailed view for TGME49_313390

Basic information

TDR Targets ID: 258823
Toxoplasma gondii, ribosomal protein RPL6
Source Database / ID:  ToxoDB 

pI: 11.4709 | Length (AA): 282 | MW (Da): 31222 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01159   Ribosomal protein L6e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
127 218 2joy (A) 2 92 24.00 0.00081 0.41 0.601441 -0.2
128 237 2joy (A) 3 94 34.00 0.00032 0.29 0.525771 0.37
200 253 3v6i (B) 35 86 37.00 0.63 0.03 0.517189 -0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 5XXB:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. Gregory Hehl AB Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 Oocyst. Fritz HM
Show/Hide expression data references
  • Gregory ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Sibley/Greg ToxoDB

Orthologs

Ortholog group members (OG5_127206)

Species Accession Gene Product
Arabidopsis thaliana AT1G74060   60S ribosomal protein L6-2
Arabidopsis thaliana AT1G18540   60S ribosomal protein L6-1
Arabidopsis thaliana AT1G74050   60S ribosomal protein L6-3
Babesia bovis BBOV_II000880   ribosomal protein L6e, putative
Brugia malayi Bm1_45400   60S ribosomal protein L6
Caenorhabditis elegans CELE_R151.3   Protein RPL-6
Cryptosporidium hominis Chro.70493   60S ribosomal protein L6 (YL 16 like)
Cryptosporidium parvum cgd7_4460   60S ribosomal protein L6
Dictyostelium discoideum DDB_G0292460   60S ribosomal protein L6
Drosophila melanogaster Dmel_CG11522   Ribosomal protein L6
Echinococcus granulosus EgrG_000446300   60s ribosomal protein l6
Echinococcus granulosus EgrG_000322250   large subunit ribosomal protein 6
Entamoeba histolytica EHI_045300   60S ribosomal protein L6, putative
Entamoeba histolytica EHI_093580   60S ribosomal protein L6, putative
Entamoeba histolytica EHI_067520   60S ribosomal protein L6, putative
Entamoeba histolytica EHI_140550   60S ribosomal protein L6, putative
Echinococcus multilocularis EmuJ_000322250   large subunit ribosomal protein 6
Echinococcus multilocularis EmuJ_000446300   60s ribosomal protein l6
Homo sapiens ENSG00000089009   ribosomal protein L6
Leishmania braziliensis LbrM.33.0760   60S ribosomal protein L6, putative
Leishmania braziliensis LbrM.15.1040   60S ribosomal protein L6, putative
Leishmania infantum LinJ.15.1060   60S ribosomal protein L6, putative
Leishmania infantum LinJ.33.0770   60S ribosomal protein L6, putative
Leishmania major LmjF.15.1000   60S ribosomal protein L6, putative
Leishmania major LmjF.33.0720   60S ribosomal protein L6, putative
Leishmania mexicana LmxM.32.0720   60S ribosomal protein L6, putative
Leishmania mexicana LmxM.15.1000   60S ribosomal protein L6, putative
Loa Loa (eye worm) LOAG_02225   60S ribosomal protein L6
Mus musculus ENSMUSG00000091086   predicted gene 5428
Mus musculus ENSMUSG00000029614   ribosomal protein L6
Neospora caninum NCLIV_056680   hypothetical protein
Oryza sativa 4329831   Os02g0591700
Oryza sativa 4336140   Os04g0473400
Plasmodium berghei PBANKA_1351900   60S ribosomal protein L6-2, putative
Plasmodium falciparum PF3D7_1338200   60S ribosomal protein L6-2, putative
Plasmodium knowlesi PKNH_1263100   60S ribosomal subunit protein L6e, putative
Plasmodium vivax PVX_082840   60S ribosomal protein L6, putative
Plasmodium yoelii PY02722   60S ribosomal protein L6, putative
Saccharomyces cerevisiae YML073C   ribosomal 60S subunit protein L6A
Saccharomyces cerevisiae YLR448W   ribosomal 60S subunit protein L6B
Schistosoma japonicum Sjp_0078050   ko:K02934 large subunit ribosomal protein L6e, putative
Schistosoma mansoni Smp_038510.1   60S ribosomal protein L6
Schistosoma mansoni Smp_038510.2   60S ribosomal protein L6
Schmidtea mediterranea mk4.003538.00   60S ribosomal protein L6
Schmidtea mediterranea mk4.000039.10   60S ribosomal protein L6
Schmidtea mediterranea mk4.004626.00   60S ribosomal protein L6
Trypanosoma brucei gambiense Tbg972.10.13750   60S ribosomal protein L6, putative
Trypanosoma brucei Tb927.10.11390   60S ribosomal protein L6, putative
Trypanosoma congolense TcIL3000_10_9620   60S ribosomal protein L6, putative
Trypanosoma cruzi TcCLB.504949.14   60S ribosomal protein L6, putative
Trypanosoma cruzi TcCLB.507709.50   60S ribosomal protein L6, putative
Trypanosoma cruzi TcCLB.506577.54   60S ribosomal protein L6, putative
Trypanosoma cruzi TcCLB.505843.20   60S ribosomal protein L6, putative
Toxoplasma gondii TGME49_313390   ribosomal protein RPL6
Theileria parva TP04_0493   60S ribosomal protein L6e, putative
Trichomonas vaginalis TVAG_099510   conserved hypothetical protein
Trichomonas vaginalis TVAG_303050   conserved hypothetical protein
Trichomonas vaginalis TVAG_163900   conserved hypothetical protein
Trichomonas vaginalis TVAG_102980   conserved hypothetical protein
Trichomonas vaginalis TVAG_119970   conserved hypothetical protein
Trichomonas vaginalis TVAG_459170   conserved hypothetical protein
Trichomonas vaginalis TVAG_329630   conserved hypothetical protein

Essentiality

TGME49_313390 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.11390 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.11390 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.11390 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.11390 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R151.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_R151.3 Caenorhabditis elegans larval arrest wormbase
CELE_R151.3 Caenorhabditis elegans slow growth wormbase
CELE_R151.3 Caenorhabditis elegans sterile wormbase
PBANKA_1351900 Plasmodium berghei Essential plasmo
TGME49_313390 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TGME49_313390 (Toxoplasma gondii), ribosomal protein RPL6
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